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CADENCE: Combination analgesic development for enhanced clinical efficacy

by CPN Admin | Apr 07, 2017
Leader(s): Ian Gilron, Luda Diatchenko, Nader Ghasemlou, Elizabeth Vandenkerkhof and Scott Duggan
Institution(s): Queen’s University, McGill University, University of Manitoba
Other Members: Dongsheng Tu, Ronald Holden, Roumen Milev, Alan
Jackson, Tanveer Towheed

This study is a double-blind, double-dummy, randomized, controlled, 3 period crossover clinical trial comparing a combination of the anticonvulsant, pregabalin (PGB), with the non-sedating antioxidant, alpha-lipoic acid (ALA) to each monotherapy in chronic pain. Project outputs will advance knowledge about rational combination
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