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CPN Funded Research Projects

Chronic pain is one of the most common reasons to seek healthcare and miss work or school. One in five Canadians is living with chronic pain, and suffer profound adverse impacts on their physical, emotional and occupational functions. In North America alone, chronic pain costs at least $600 billion annually, exceeding costs associated with heart disease, cancer and diabetes. Though progress has been made in pain research, there are many issues that still need to be addressed.
Within the Chronic Pain Network, People Living with Pain help inform research priorities. Network projects include population, behavioural and basic studies, as well as clinical trials, with the goal of creating transformational change in the areas of preclinical, behavioural, clinical, health services, population health and patient engagement research.
Below is a listing of Chronic Pain Network affiliated research projects.

Information Box Group

Aboriginal Children's Hurt & Healing Initiative National: Gathering and Sharing Knowledge to Improve Aboriginal Children's Pain Assessment and Management

Leader(s): Margot Latimer (Co-PI), Sharon Rudderham (Co-PI)
National Community Engagement & Research Coordinator: John R. Sylliboy
Institution(s): IWK Health Centre, Centre for Pediatric Pain Research, Eskasoni Health Centre, Dalhousie University
Other Members: Finley, A.; Harman, K.; Mushquash, C.; Paul, K.; Chorney, J.; Hutt-MacLeod, D.; Perley-Dutcher, L.

Expansion of the Aboriginal Children’s Hurt & Healing initiative to encompass six additional communities, including four more First Nations (Alberta, BC, Ontario and Quebec), one Inuit (Labrador) and one Metis (Manitoba) community. The Aboriginal Children’s Hurt & Healing (ACHH) Initiative was created out of a need to better understand the issue of chronic pain in Aboriginal pediatric populations. Aboriginal children experience higher rates of painful conditions including, but not limited to, dental pain, ear pain and headaches. However, pain management and treatment remains inadequate. ACHH Initiative has engaged four Atlantic Canadian First Nations communities (3 Mi’kmaq, 1 Maliseet) to begin to better understand the prevalence, experience and conceptualization of pain.

Development of a Web Application to Help Teens with Juvenile Arthritis and their Caregivers Make Informed and Personalized Decisions About Pain Management Options

Leader(s): Karine Toupin April (PI)
 Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa
Other Members: Stinson J, Huber AM, Couchman D, Ragusa M, Sachs H, Sivakumar A, Gaboury I, Duffy CM, Morgan E, Brosseau L, Li LC, Brinkman W, Bisch M, Cohen J, Stringer E, Légaré F, Proulx L, Sirois A, Junkin L, Cavallo S, Fortin PR, Tugwell P

An intervention to help teens with Juvenile Idiopathic Arthritis, and their parents, become informed about pain management options, make dicisions that match with what is important to them, and be engaged in their own care.

Biobank of Biological Samples from Chronic Pain Patients from Canadian Registries and Screening for Molecular Markers

Leader(s): Luda Diatchenko
Institution(s)McGill University
Other Members: Quebec Pain Network

Creation of a biobank of biological samples, including DNA, RNA and plasma proteins, obtained from patients in the registries of SPOR Network grant partners. Samples will be used to identify molecular markers of the chronicity of pain conditions and their response to specific treatments.

Cadence: Combination Analgesic Development for Enhanced Clinical Efficacy

Leader(s): Ian GilronLuda DiatchenkoNader Ghasemlou, Elizabeth Vandenkerkhof, and Scott Duggan
Institution(s): Queen’s UniversityMcGill UniversityUniversity of Manitoba
Other Members: Dongsheng Tu, Ronald Holden, Roumen Milev, Alan Jackson, Tanveer Towheed

This study is a double-blind, double-dummy, randomized, controlled, 3 period crossover clinical trial comparing a combination of the anticonvulsant, pregabalin (PGB), with the non-sedating antioxidant, alpha-lipoic acid (ALA) to each monotherapy in chronic pain. Project outputs will advance knowledge about rational combination

Canadian Surveillance Study of Complex Regional Pain Syndrome in Children and Youth

Leader(s)Krista Baerg (PI), Susan Tupper (co-PI) and Allen Finley (co-PI)
Institution(s): University of Saskatchewan/Saskatoon Health RegionDalhousie University
Other Members: Canadian Pediatric Pain Clinics

A population study exploring Complex Regional Pain Syndrome (CRPS) cases, in children and youth, presenting to paediatricians and pediatric chronic pain centres across Canada. With a proposed surveillance duration of two years, and utilizing the established methodology of the Canadian Paediatric Surveillance Program, research will provide important incidence data and describe pediatric case characteristics. This foundational data will promote early recognition and treatment of CRPS in childhood and adolescence, as well as inform the education of pain health professionals both nationally and internationally.

Chronic Pain in the Emergency Department: Understanding Contributing Factors to Improve Health Care Outcomes, Health Care Utilization and Prescription Opiod Abuse

Leaders: Patricia Poulin and Catherine Smyth
Institution(s): The Ottawa Hospital Research InstituteSt. Joseph’s Care Group and Northern Ontario School of Medicine
Other Member(s): Bryan MacLeod

This study seeks to examine how chronic pain is handled in the Emergency Department; ascertain the proportion of patient with chronic pain, who are frequent users of the Emergency Department, who have had access to self-management, inter-disciplinary interventions or to a pain specialist; ascertain stakeholders’ expectations of how chronic pain should be managed in the Emergency Department; and to explore the different reasons for presentation, care provided, care expectations and access to self-management, interdisciplinary program or pain specialists. The study also seeks to describe characteristics of patients with chronic pain who frequently use the Emergency Department to address their pain.

Circadian Control of Chronic Pain

Leader(s): Nader Ghasemlou, PhD & Ian Gilron, MD
Institution(s): Queen’s University
Other Members: Luda Diatchenko, PhD (McGill); Elizabeth vandenKerkhof, PhD (Queen’s University); Scott Duggan, MD (Queen’s University); non-CPN members: Qingling Duan, PhD (Queen’s University), Brian Kwon, MD (UBC)

The study seeks to identify novel mechanisms underlying chronic pain that are affected by circadian rhythms by describing fluctuations in the intensity of pain reported by chronic pain sufferers, and identifying the molecular cues responsible for the generation of central pain in spinal cord injury patients.

Epidemiological Investigations of Chronic Pain Conditions and Psychiatric Disorders

Leader(s): Dr. Renée El-Gabalawy
Institution(s): University of Manitoba
Other Members: Dr. Brian Csupak, Dr. Eric Jacobsohn, Dr. Gordon Asmundson, Jordana Sommer, Elena Bilivicus

A series of epidemiological investigations will aim to understand the complex relationship between chronic pain conditions and psychiatric disorders. In both population-based Canadian and US samples, we will establish co-morbidity trends, mechanisms to elucidate co-occurrence, and health and disability-related implications of co-morbidities.

ICanCope: Randomized Controlled Trial of a Smartphone and Web-Based Application to Manage Pain in Adolescents and Young Adults (AYA) with Chronic Pain

Leader(s): Jennifer Stinson
Institution(s): Hospital for Sick Children (site lead), Centre for Global eHealth Innovation (University Health Network), Alberta Children’s HospitalMount Sinai HospitalIWK Health CentreQueen Elizabeth II HealthSciences CentreAlberta Health ServicesStollery Children’s Hospital
Other Members: Lalloo, C.; Campbell, F.; Gordon, A.; Chorney, J.; Clark, J.; Simmonds, M.; Rashiq, S.; Jibb, L.; Dick, B.; Forgeron, P.; Ingelmo, P.; Montgomery, L.; Ruskin, D.; Tupper, S.; Victor, C.; Ware, M.; Palermo, T.

The project seeks to develop and evaluate iCanCope, the first integrated smartphone and web-based pain management program for AYA with persistent pain.

Improving Personalized Medicine Through Discovery of Pain Mechanisms Using Patient-Derived Neurons

Leader(s): Steven A. Prescott, MD, PhD; and Michael W. Salter, MD, PhD
Institution(s): The Hospital for Sick Children
Other Members: James Ellis, PhD; and James Whitlock, MD

A basic research study that uses patient-derived sensory neurons to compare cellular changes in leukemia patients who are susceptible or resistant to chemotherapy-induced neuropathy. The long term results are intended to help develop patient-specific treatments against neuropathic pain.

Individual Phenotypes of Chronic Pain: The Dynamic Pain Connectome Towards Painometer Development and Neuroethics

Leader(s): Karen D. Davis, PhD; Cyril Schneider, PhD
Institution(s): University Health NetworkUniversite Laval & CHU of Quebec
Other Members: Dwight Moulin, Petra Schweinhardt, McGill Research Group

A basic study seeking to identify key indicators of the dynamic pain connectome, representing individual pain sensitivities; genotypic characteristics; changes of brain structure and function; changes of sensorimotor control (body manifestations); changes in behaviour (e.g., kinesiophobia); resilience and treatment response. A multidisciplinary approach will link pain perception with brain findings derived from task/resting-state fMRI and static/dynamic connectivity in patients before and after treatment. Data will be used to develop a machine learning model that links the dynamic pain connectome in each individual and their behavioural deficits and pain. This can then be used to determine treatments best suited to each patient. A framework for neuroethics, legal and societal challenges related to brain imaging/function and physiopathology proxies of pain will also be established.

Socially Marginalized Populations: Adapting PainBC's Programs to meet Unique Needs

Leader(s): Kenneth D. Craig
Institution(s): University of British Columbia
Other Members: PainBC

This study seeks to investigate barriers faced by socially marginalized populations when seeking access to pain management treatments. It will do so through literature reviews, assembling current knowledge, self-report of representatives of socially marginalized populations in the LGBTQ2S, refugees and immigrant newcomers and Indigenous populations using focus groups, and examine how Pain BC’s programs can be adapted for effectiveness with marginalized populations.

Music Program for Chronic Pain

LeadersLee Bartel (PhD)
Institutions: Wasser Pain Management CentreMount Sinai HospitalUniversity of Toronto, Faculty of MusicFred A Litwin and Family Centre in Genetic Medicine
Other members: Larry Picard (MD), Thenille Braun Janzen (PhD), Denise Paneduro (MA), Veronica Vuong (BMus), Marilyn Galonski (RN), Leah Pink (NP), Azar Azad (MLD, PhD), Ana Andreazza (PhD), Jed Meltzer (PhD), Hanna Faghfoury (MDCM, FRCPC)

An examination of the effects of a non-medical and self-administered therapy option for the management of chronic pain, i.e., Rhythmic Sensory Stimulation and Music. Research will also investigate the mechanisms underlying the use of low-frequency rhythmic sensory stimulation and music as a complementary treatment for chronic pain.

Pain in Older Adults

Leader(s): Thomas Hadjistavropoulos, Ph.d, FCAHS
Institution(s): University of Regina
Other Members: Lisa Lix, Ph.D., Harminder Guliania, Ph.D., Ying MacNab, Ph.D.

This work focuses on three areas:

  • An examination of the cost of pain in long term care;
  • pain cues used by observers to draw conclusions about pain in older persons
  • pain self-management interventions for older adults.

Prediction of Chronic Pain after Upper Extremity Fracture or Arthroplasty

Leader(s): Joy MacDermidDave Walton
Institution(s): University of Western OntarioHand and Upper Limb Centre
Other Members: HULC Surgeon Investigators: Ruby Grewal, Ken Faber, George Athwal

This projects seeks to:

  1. determine if sex/gender measurement biases exist in the network pain measures;
  2. identify sex/gender factors that contribute to incident chronic pain after distal radius fracture or worsening pain after upper extremity joint arthroplasty;
  3. examine clinician and patient perspectives of on peri-operative pain management, gender expectations and decision pathways for choices in pain management.

Proteomic Analysis of Chronic Pain to Identify New Therapeutic Targets and Biomarkers

Leader(s): Nader Ghasemlou, PhD (Queen’s University); Luda Diatchenko, PhD (McGill); Ian Gilron, MD (Queen’s University)
Institution(s): Queen’s University
Other Members: Scott Duggan, MD (Queen’s University); Elizabeth VanDenKerkhof, PhD (Queen’s University); Qingling Duan, PhD (Queen’s University), Brian Kwon, MD (UBC), Judith Steen, PhD (Boston Children’s Hospital)

The project seeks to identify patients for proteomic characterization who have already undergone genomic screening and to identify patients most closely grouped in terms of age, sex, race and disease progression/pain outcomes.

Randomized Control Trials of Neuromodulcation to Treat Chronic Low Back Pain and Complex Regional Pain Syndrome

Leader(s): Cyril Schneider
Institution(s): Université Laval
Other Members: CEGDC (Center for Excellence of Chronic Pain Management, Province of Québec), including pain centres; all Canadian pain researchers with neurostimulation and MRI

A randomized control trial of neuromodulation, aiming to collect evidence-based data on noninvasive brain stimulation and noninvasive peripheral stimulation after-effects in chronic lower back pain and complex regional pain syndrome and detecting factors predictive of success (personalized health care).

Strategic Approaches to Personalized Diagnosis and Treatment in Chronic Pain

Leaders: Serge Marchand and Louis Gendron, with Phillippe Sarret and  Nicolas Beaudet
Institution(s): Université de Sherbrooke and Centre de Recherche du CHUS
Other Member(s): Quebec Pain Research Network (QPRN), Pain Research Centers and Pain Clinics in Quebec and Canada

The project seeks to develop and validate standard procedures to measure excitatory and inhibitory mechanisms in conditioned pain modulation, and to establish these procedures across Pain Centers and Pain Clinics of the Network.

Targeted Pain Therapies for Cancer Patients

Leader(s): Drs. Gurmit Singh and Jan Huizinga
Institution(s): McMaster University
Other Member(s): Drs. Murray Webb – (CDRD Vancouver); John Valliant – (CPDC McMaster); Paul Schaffer – (TRIUMF, UBC)

This study begins as a retrospective study using biobank samples to investigate biomarkers focused on breast, prostate and lung cancers that have metastasized to the bone and cause severe chronic pain. A prospective study biomarker analysis will be investigated in baseline and cancer patients with and without cancer pain, ultimately resulting in validating biomarkers before and after treatment with novel agents. This data is critical to advance future therapeutics for cancer-induced pain.

The Role of Parent Mental Health in Pediatric Chronic Pain

Leader(s): Melanie Noel
Institution(s): Alberta Children’s Hospital (site lead), University of Calgary/Foothills Medical CentreHospital for Sick ChildrenIWK Health Centre
Other Member(s): Syed, N.; Rasic, N.; Vinall, J.; Bray, S.; Harris, A.; Palermo, T.; Kazak, A.; Vervoort, T.; Sears, C.; Stinson, J.; Finley, A.; Latimer, M.; Chorney, J.

A multi-site, clinical research study seeking to determine the cognitive, behavioural, and biological mechanisms underlying the relationship between parental mental health issues and children’s pain outcomes in a sample of youth with chronic pain.

The Systematic Merging of Biology, Mental Health, and Environment (SYMBIOME) Longitudinal Databanking Project

Leader(s): David WaltonJoy MacDermid, Jim Elliott, Walter Siqueira, Lynn Cooper, Brian Corneil, Eldon Loh, Gordon Good, Siobhan Schabrun, Jordan Miller
Institution(s): University of Western OntarioMcMaster UniversityMcGill UniversityUniversity of British Columbia,Queen’s UniversityNorthwestern University (Chicago), Western Syndey University (New South Wales), University of North Carolina at Chapel Hill, Canadian Pain Coalition, Gordon Good Law Offices
Other Member(s): Bill Aal, David Holdsworth, Douglas Fraser, David Seminowicz, Greg Gloor, Gunter Siegmund, Jim Dickey, Jeff Dixon, Joe Gati, Kevin Shoemaker, Linda Carroll, Marnin Heisel, Paul Tremblay, Samuel McLean, Ruth Lanius, Stan Van Uum, Tim Wideman, Trevor Birmingham. Trainees: Joshua Lee, Sadia Siraj. Research Assistants: Paul Phares, Ryan Power.

The SYMBIOME databank seeks to establish a robust, rigourously-collected and maintained longitudinal acute-to-recovered or acute-to-chronic databank of biological, psychological and social indicator variables that will allow advanced exploratory and confirmatory analyses of the trajectory and causes of pain and disability following acute musculoskeletal trauma